Orexin-A (a neuropeptide in the hypothalamus) plays an important role in many physiological functions. including the regulation of glucose metabolism. We have previously found that the development of post-ischemic glucose intolerance is one of the triggers of ischemic neuronal damage. which is suppressed by hypothalamic orexin-A. https://www.bekindtopets.com/save-now-Aqua-Pure-3MFF101-Full-Flow-Drinking-Water-System-Replacement-Cartridge-flash-choice/