Sustained activation of JAK/STAT3 signaling pathway is classically described in Multiple Myeloma (MM). One explanation could be the silencing of the JAK/STAT suppressor genes. through the hypermethylation of SHP-1 and SOCS-1. previously demonstrated in MM cell lines or in whole bone marrow aspirates. https://parisnaturalfoodes.shop/product-category/whitening-plus-cool-mint-toothpaste/