In amyotrophic lateral sclerosis (ALS) spinal motor neurons (SpMN) progressively degenerate while a subset of cranial motor neurons (CrMN) are spared until late stages of the disease. Using a rapid and efficient protocol to differentiate mouse embryonic stem cells (ESC) to SpMNs and CrMNs. we now report that ESC-derived CrMNs accumulate less human (h)SOD1 and insoluble p62 than SpMNs ... https://herbsdailyes.shop/product-category/black-seed/