Although structurally and biochemically similar to the cellular prion (PrP(C)). doppel (Dpl) is unique in its biological functions. There are no reports about any neurodegenerative diseases induced by Dpl. However the artificial expression of Dpl in the PrP-deficient mouse brain causes ataxia with Purkinje cell death. https://www.mariameetsanna.com/product-category/hand-cream/