Abstract Background Glioblastoma (GBM) is the most malignant primary tumor in the brain. with poor prognosis and limited effective therapies. Although Bevacizumab (BEV) has shown promise in extending progression-free survival (PFS) treating GBM. there is no evidence for its ability to prolong overall survival (OS). https://www.elphonsolam.com/product-category/bubbles/